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. Author manuscript; available in PMC: 2008 Nov 12.
Published in final edited form as: Eur J Neurosci. 2006 Aug;24(4):1109–1116. doi: 10.1111/j.1460-9568.2006.04972.x

Fig. 1.

Fig. 1

Brain-derived neurotrophic factor (BDNF) enhances excitatory synaptic transmission in suprachiasmatic nucleus (SCN) neurons. Spontaneous excitatory postsynaptic currents (sEPSCs) were recorded from the ventral SCN neuron during the night in the presence of tetrodotoxin (0.5 μM) and bicuculline (25 μM). (A) Examples of sEPSCs recorded from a neuron immediately before and after treatment with BDNF (100 ng/mL, 240 s). (B) Average sEPSC waveform recorded in this same neuron before (gray line) and after (black line) treatment with BDNF. (C) Application of BDNF increased the frequency and amplitude of the sEPSCs whereas K252a (100 nM, 240 s) decreased these same values. Neurons that did not respond to the BDNF treatment were not included in this analysis. Data are shown as means ± SEM. *Significance at P < 0.05.