Figure 8. Pain-related behaviors induced by NH₄Cl injection into mouse hind paws.

(A) The time spent licking or biting induced by injection of NH₄Cl (100 mM) with or without RR (100 μM) for 10 minutes in WT mice (n = 9) or with saline as a control (n = 6). **P < 0.01 versus treatment with NH₄Cl alone. (B) Time course of licking or biting induced by injection of NH₄Cl (100 mM) for 10 minutes in WT (n = 8) or TRPA1-deficient (TRPA1-KO) mice (n = 5). ^†P < 0.01. (C) The time spent licking or biting induced by injection of NH₄Cl (100 mM) for 10 minutes in WT (n = 8) or TRPA1-deficient mice (n = 5). ^†P < 0.01.