Table 1. Effects of MdOS on the activity of a panel of tyrosine kinases.

Kinase	IC50 (µg/ml)
HER-2	0.13±0.09
EGFR	0.28±0.01
VEGFR2	1.8±0.6
VEGFR1	2.4±0.4
PDGFRβ	1.8±0.3
c-Kit	4±2
c-Src	0.7±0.2
FGFR1	0.68±0.08
FGFR2	>20

Kinases activity was assayed by ELISA. Concentrations that cause 50% inhibition (IC₅₀) are shown as mean±SD of three to six separate experiments performed in duplicate. EGFR, epidermal growth factor receptor; VEGFR, vascular endothelial growth factor receptor; PDGFR, platelet derived growth factor receptor; FGFR, fibroblast growth factor receptor.