Figure 2.

Spontaneous Electrical Activity and E₂-Induced Activation of GIRK Current in Identified GnRH Neurons

A, Inhibition of AP firing during E₂ treatment and reversal of the inhibitory action and transition to the stimulatory action of E₂ on AP firing during treatment with an ERα antagonist. B, Stimulation of AP firing by E₂ and transition to the stimulatory action of E₂ on AP firing during treatment with an ERα antagonist. C, Inhibition of AP firing by ERα agonist and recovery of AP firing during washout period. D, ERβ agonist-induced increase in spontaneous AP firing in cultured hypothalamic GnRH neurons and recovery of AP firing during washout period. Ag., Agonist; Ant., antagonist.