Table 1.

LXR Ligand Properties

Ligand	Agonism	NCoR Dismissal (FRET)	Gal-LXRα	siNCoR	NCoR O/E	hABCA1-Luc	Gene Expression
GSK224	Weak partial	−7%	↑	5.2↑	1.3↓	↑	↑↑ABCA1
							↑↑FAS
							↑↑SREBP1
GW965	Partial	−23%	↑↑↑	3.7↑	1.8↓	↑↑	↑↑ABCA1
							↑↑FAS
							↑↑SREBP1
T091317	Full	−94%	↑↑↑↑↑	2.0↑	1.2↓	↑↑↑	↑↑ABCA1
							↑↑↑FAS
							↑↑ SREBP1

NCoR O/E, Overexpression of NCoR.