Table 3.
Binding Sites for Estrogen-Regulated TF in the Blood Vessel Are Overrepresented in Estrogen-Regulated Vascular Genes
| Estrogen-Regulated Gene Set | Overrepresented Estrogen-Regulated TF Binding Site | TF Gene Symbol | No. of Genes with Overrepresented Binding Site | Total No. of Overrepresented Estrogen-Regulated TF Binding Sites per Time Point |
|---|---|---|---|---|
| 2 h, estrogen-repressed | Myocyte enhancer factor 2a | Mef2a | 9 | |
| 2 h, estrogen-induced | Nuclear factor I/B | NfIb | 3 | 12 |
| 4 h, estrogen-repressed | Hepatic leukemia factor | Hlf | 24 | |
| Ras responsive element binding protein 1 | Rreb1 | 14 | ||
| Myocyte enhancer factor 2a | Mef2a | 3 | ||
| Nuclear factor I/B | NfIb | 7 | ||
| 4 h, estrogen-induced | Ras responsive element binding protein 1 | Rreb1 | 8 | 56 |
| 8 h, estrogen-repressed | Myocyte enhancer factor 2a | Mef2a | 11 | |
| Ras responsive element binding protein 1 | Rreb1 | 13 | ||
| Nuclear factor I/B | NfIb | 12 | ||
| 8 h, estrogen-induced | D site albumin promoter binding protein | Dbp | 47 | |
| Myocyte enhancer factor 2a | Mef2a | 2 | 85 |
The table lists estrogen-regulated transcription factors with overrepresented binding sites in the promoters of the genes in each of six estrogen-regulated vascular gene sets (2, 4, or 8 h hormone treatment, estrogen repressed or induced). The number of genes containing the overrepresented binding site in each gene set and the total number at each time point are also listed.