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. 2008 Aug 26;93(11):4532–4541. doi: 10.1210/jc.2008-1001

Table 2.

Correlation of metabolic traits with ERSR in sample 1

Gene type trait r/p Proximal ER sensors
sp XBP1 Protein degradation
HSPA5 ATF6α EIF2AK3 EDEM1 TRAF2
BMI r 0.51 0.48 0.48 0.43 0.45 0.38
p 6 × 10−6 2 × 10−5 2 × 10−5 0.0001 0.00008 0.001
Waist circ r 0.46 0.43 0.44 0.39 0.38 0.31
p 5 × 10−5 0.0002 0.0001 0.0007 0.0009 0.009
Hip circ r 0.47 0.44 0.44 0.43 0.43 0.35
p 4 × 10−5 9 × 10−5 0.0001 0.0001 0.00015 0.002
Waist to hip ratio r 0.25 0.21 0.23 0.12 0.13 0.1
p 0.037 0.07 0.05 0.32 0.26 0.4
PFAT r 0.55 0.53 0.52 0.46 0.52 0.42
p 6 × 10−7 2 × 10−6 3 × 10−6 5 × 10−5 2 × 10−6 0.0002
Trunk: leg r 0.23 0.25 0.214 0.2 0.19 0.17
p 0.06 0.037 0.07 0.1 0.12 0.16
SI r −0.21 −0.29 −0.18 −0.26 −0.17 −0.16
p 0.08 0.01 0.14 0.027 0.14 0.16
AIRg r 0.05 0.018 −0.01 0.03 0.05 0.059
p 0.68 0.89 0.93 0.79 0.66 0.62
DI r −0.1 −0.19 −0.14 −0.16 −0.07 −0.05
p 0.42 0.1 0.24 0.19 0.56 0.656
Fasting glucose r 0.2 0.25 0.19 0.19 0.18 0.1
p 0.09 0.032 0.11 0.11 0.12 0.39
2-h glucose r 0.04 0.11 0.07 0.11 0.11 0.12
p 0.75 0.33 0.54 0.36 0.36 0.32
Insulin AUC r 0.11 0.19 0.1 0.15 0.15 0.09
p 0.36 0.1 0.39 0.21 0.22 0.44
Ins/glu AUC r 0.08 0.15 0.07 0.16 0.12 0.04
p 0.5 0.2 0.55 0.18 0.33 0.73

Correlations of traits with expression of ER stress genes in sc adipose. Underlined cells are statistically significance. The second column (r/p) gives either the partial correlation coefficient (r) or the attached significance (p). For space considerations, genes with no significant correlations are not shown: ERN1, total XBP1, and CHOP. Note that approved human gene codes are used throughout. Commonly used aliases are GRP78/BIP (HSPA5), PERK (EIF2AK3), p58IPK (DNAJC3), and ORP150 (HYOU1). circ, Circumference; Insulin AUC, insulin area under curve from oral glucose tolerance test study; Ins/glu AUC, ratio of insulin to glucose area under curve from oral glucose tolerance test visit; PFAT, percent fat from DXA; SI from MINMOD; sp XBP1, spliced XBP1 by real-time assay; Trunk:leg, ratio of mean percent fat in both legs to trunk from DXA.