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. 2008 Aug 26;93(11):4532–4541. doi: 10.1210/jc.2008-1001

Table 3.

Correlations of ERSR genes with metabolic traits, chaperones and apoptosis pathway genes

Gene type trait r/p Chaperones
Apoptosis pathway
HYOU1 DNAJC3 CALR STC2 ATF4 GADD34 ATF3
BMI r 0.51 0.53 0.53 0.62 0.3 0.36 0.48
p 6 × 10−6 2 × 10−6 2 × 10−6 6 × 10−9 0.01 0.002 2 × 10−5
Waist circ r 0.51 0.47 0.5 0.62 0.24 0.35 0.5
p 6 × 10−6 3 × 10−5 1 × 10−5 8 × 10−9 0.045 0.003 1 × 10−5
Hip circ r 0.52 0.5 0.49 0.59 0.26 0.4 0.44
p 3 × 10−6 9 × 10−6 1 × 10−5 3.8 × 10−8 0.03 0.0006 9 × 10−5
Waist to hip ratio r 0.25 0.21 0.27 0.37 0.1 0.13 0.34
p 0.03 0.07 0.02 0.001 0.42 0.29 0.003
PFAT r 0.54 0.57 0.52 0.65 0.31 0.38 0.43
p 1 × 10−6 1 × 10−7 2 × 10−6 6.10−10 0.008 0.0009 0.0001
Trunk: leg r 0.23 0.23 0.27 0.37 0.19 0.4 0.37
p 0.06 0.05 0.02 0.001 0.11 0.0004 0.0001
SI r −0.2 −0.23 −0.25 −0.35 −0.21 −0.37 −0.26
p 0.084 0.05 0.04 0.002 0.08 0.001 0.025
AIRg r 0.2 0.06 0.11 0.21 −0.006 0.052 −0.07
p 0.083 0.64 0.36 0.07 0.96 0.66 0.54
DI r 0.075 −0.1 −0.06 −0.02 −0.16 −0.21 −0.27
p 0.53 0.38 0.6 0.83 0.18 0.08 0.02
Fasting glucose r 0.17 0.22 0.26 0.13 0.001 0.2 0.19
p 0.16 0.06 0.03 0.28 0.99 0.1 0.11
2-h glucose r 0.07 0.08 0.11 0.16 0.13 0.24 0.15
p 0.55 0.51 0.35 0.18 0.27 0.038 0.21
Insulin AUC r 0.19 0.17 0.15 0.28 0.12 0.3 0.23
p 0.11 0.15 0.22 0.02 0.3 0.009 0.05
Ins/glu AUC r 0.19 0.14 0.1 0.25 0.1 0.26 0.21
p 0.1 0.23 0.42 0.04 0.38 0.03 0.08

Correlations of traits with expression of ER stress genes in sc adipose. Underlined cells are statistically significance. The second column (r/p) gives either the partial correlation coefficient (r) or the attached significance (p). For space considerations, genes with no significant correlations are not shown: ERN1, total XBP1, and CHOP. Note that approved human gene codes are used throughout. Commonly used aliases are GRP78/BIP (HSPA5), PERK (EIF2AK3), p58IPK (DNAJC3), and ORP150 (HYOU1). circ, Circumference; Insulin AUC, insulin area under curve from oral glucose tolerance test study; Ins/glu AUC, ratio of insulin to glucose area under curve from oral glucose tolerance test visit; PFAT, percent fat from DXA; SI from MINMOD; sp XBP1, spliced XBP1 by real-time assay; Trunk: leg, ratio of mean percent fat in both legs to trunk from DXA.