Table 3.
LDDST-serum cortisol
| Criterion | Sensitivity | CI95 | Specificity | CI95 | +LR | −LR | +PV | −PV |
|---|---|---|---|---|---|---|---|---|
| ≥1 | 100.00 | 71.3–100.0 | 0.00 | 0.0–16.3 | 1.00 | 34.4 | ||
| >1 | 90.91 | 58.7–98.5 | 80.95 | 58.1–94.4 | 4.77 | 0.11 | 71.4 | 94.4 |
| >1.1 | 90.91 | 58.7–98.5 | 90.48 | 69.6–98.5 | 9.55 | 0.10 | 83.3 | 95.0 |
| >1.2a | 90.91 | 58.7–98.5 | 95.24 | 76.1–99.2 | 19.09 | 0.095 | 90.9 | 95.2 |
| >2.5 | 81.82 | 48.2–97.2 | 95.24 | 76.1–99.2 | 17.18 | 0.19 | 90.0 | 90.9 |
| >3 | 63.64 | 30.9–88.8 | 95.24 | 76.1–99.2 | 13.36 | 0.38 | 87.5 | 83.3 |
| >4 | 54.55 | 23.5–83.1 | 95.24 | 76.1–99.2 | 11.45 | 0.48 | 85.7 | 80.0 |
| >5 | 45.45 | 16.9–76.5 | 95.24 | 76.1–99.2 | 9.55 | 0.57 | 83.3 | 76.9 |
| >7.1 | 36.36 | 11.2–69.1 | 95.24 | 76.1–99.2 | 7.64 | 0.67 | 80.0 | 74.1 |
| >7.3 | 36.36 | 11.2–69.1 | 100.00 | 83.7–100.0 | 0.64 | 100.0 | 75.0 | |
| >8 | 27.27 | 6.3–60.9 | 100.00 | 83.7–100.0 | 0.73 | 100.0 | 72.4 | |
| >9 | 18.18 | 2.8–51.8 | 100.00 | 83.7–100.0 | 0.82 | 100.0 | 70.0 | |
| >17 | 9.09 | 1.5–41.3 | 100.00 | 83.7–100.0 | 0.91 | 100.0 | 67.7 | |
| >18 | 0.00 | 0.0–28.7 | 100.00 | 83.7–100.0 | 1.00 | 65.6 |
a
A criterion of 1.2 μg/dl (33 nmol/liter) for serum cortisol, before oCRH administration, has the highest possible sensitivity and specificity value for the diagnosis of CS (and exclusion of PCSS) for all patients regardless of BMI; 100% sensitivity is achieved with a criterion of 1.0 μg/dl (28 nmol/liter). LR, Likelihood ratio; PV, predictive value; +, positive; −, negative.