Table 4.
Dex-oCRH stimulation test
| Criterion | Sensitivity | CI95 | Specificity | CI95 | +LR | −LR | +PV | −PV |
|---|---|---|---|---|---|---|---|---|
| ≥1 | 100.00 | 71.3–100.0 | 0.00 | 0.0–16.3 | 1.00 | 34.4 | ||
| >1 | 100.00 | 71.3–100.0 | 76.19 | 52.8–91.7 | 4.20 | 0.00 | 68.7 | 100.0 |
| >1.5 | 100.00 | 71.3–100.0 | 80.95 | 58.1–94.4 | 5.25 | 0.00 | 73.3 | 100.0 |
| >2.2 | 100.00 | 71.3–100.0 | 90.48 | 69.6–98.5 | 10.50 | 0.00 | 84.6 | 100.0 |
| >2.3 | 90.91 | 58.7–98.5 | 90.48 | 69.6–98.5 | 9.55 | 0.10 | 83.3 | 95.0 |
| >3.2a | 90.91 | 58.7–98.5 | 95.24 | 76.1–99.2 | 19.09 | 0.095 | 90.9 | 95.2 |
| >7 | 81.82 | 48.2–97.2 | 95.24 | 76.1–99.2 | 17.18 | 0.19 | 90.0 | 90.9 |
| >7.6 | 72.73 | 39.1–93.7 | 95.24 | 76.1–99.2 | 15.27 | 0.29 | 88.9 | 87.0 |
| >8.5 | 63.64 | 30.9–88.8 | 95.24 | 76.1–99.2 | 13.36 | 0.38 | 87.5 | 83.3 |
| >10 | 54.55 | 23.5–83.1 | 95.24 | 76.1–99.2 | 11.45 | 0.48 | 85.7 | 80.0 |
| >13 | 45.45 | 16.9–76.5 | 95.24 | 76.1–99.2 | 9.55 | 0.57 | 83.3 | 76.9 |
| >16 | 36.36 | 11.2–69.1 | 95.24 | 76.1–99.2 | 7.64 | 0.67 | 80.0 | 74.1 |
| >17 | 18.18 | 2.8–51.8 | 95.24 | 76.1–99.2 | 3.82 | 0.86 | 66.7 | 69.0 |
| >19 | 9.09 | 1.5–41.3 | 95.24 | 76.1–99.2 | 1.91 | 0.95 | 50.0 | 66.7 |
| >21 | 9.09 | 1.5–41.3 | 100.00 | 83.7–100.0 | 0.91 | 100.0 | 67.7 | |
| >26 | 0.00 | 0.0–28.7 | 100.00 | 83.7–100.0 | 1.00 | 65.6 |
a
A criterion of 3.2 μg/dl (88 nmol/liter) for serum cortisol, after oCRH administration, has the highest possible sensitivity and specificity value for the diagnosis of CS (and exclusion of PCSS) for all patients, regardless of BMI; 100% sensitivity is achieved with a criterion of 2.2 μg/dl (61 nmol/liter). LR, Likelihood ratio; PV, predictive value; +, positive; −, negative.