Skip to main content
. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Biol Psychiatry. 2008 Jul 26;64(11):941–950. doi: 10.1016/j.biopsych.2008.06.007

Figure 1. Mice overexpressing ΔFosB exhibited biochemical markers of reduced dopamine signaling in the NAc.

Figure 1

(A) ΔFosB mice displayed an indication of higher levels of Cdk5 than controls, similar to previous reports (Ctrl; P < 0.09). (B) pCREB levels were significantly reduced in ΔFosB mice compared to controls (P < 0.05). (C) Total CREB levels were also significantly reduced in ΔFosB mice (P = 0.05). (D) ΔFosB mice showed a significant reduction in BDNF levels in the NAc (P < 0.05). For all figures, representative bands are shown for control (C) and ΔFosB overexpressing (ΔF) mice. *Significantly different from control.