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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Biol Psychiatry. 2008 Jul 26;64(11):941–950. doi: 10.1016/j.biopsych.2008.06.007

Figure 4. High fat diet (HF) led to changes in D1 dopamine receptor binding and DARPP-32 expression in the nucleus accumbens (NAc) of ΔFosB overexpressing mice.

Figure 4

(A) Representative images of D1 autoradiography. Dotted lines indicate the region of the NAc analyzed. (B) There were no main effects on D1 binding density. (C) A trend toward increased binding area of the D1 receptor was observed following 6 wks of HF diet (P < 0.06). Post hoc testing showed this to be significant in the ΔFosB mice (P < 0.05). (D) Representative images showing in situ hybridization for DARPP-32 expression in the NAc. Dotted lines indicate the region of the NAc analyzed. (E) There was a main effect of diet (P < 0.05), as well as an interaction between diet and ΔFosB expression (P < 0.05) on DARPP-32 expression. Post hoc testing revealed that ΔFosB mice expressed reduced levels of DARPP-32 basally (P < 0.01), and showed a significant increase in expression following HF diet (P < 0.01). *Significantly different from ΔFosB chow, +significantly different from control chow.