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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: J Neurochem. 2008 Sep 11;107(5):1196–1205. doi: 10.1111/j.1471-4159.2008.05664.x

Figure 7.

Figure 7

Effect of NBO on brain edema formation and BBB permeability after 90-min MCAO with 22.5-hr reperfusion. A) Representative brain sections of the normoxic, NBO-, vehicle- and apocynin-treated rats. Significant right (ischemic) hemispheric enlargement is seen in rats of all groups. B) Quantitative image analysis showed a significant reduction of hemispheric enlargement in the NBO- or apocynin-treated rats when compared to normoxic rats. Data are expressed as mean ±SEM, n = 4 in the vehicle-treated group, n = 7 in each of other three groups. *P < 0.05 versus normoxic rats. C) Effect of NBO on BBB permeability coefficient assessed by MRI based technique. A significant increase was observed for BBB permeability coefficient in the ischemic hemisphere of both normoxic and NBO-treated rats (*P < 0.05 versus nonischemic hemisphere). NBO significantly reduced BBB permeability in the ischemic hemisphere (#P < 0.05 versus normoxic rats). Data are expressed as mean ± SEM, n = 6 in each group.