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. 2008 Oct 15;36(20):6494–6503. doi: 10.1093/nar/gkn712

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Mathematical modeling of regulated feedback loop. For simplicity, we let 1/(k_MA + α) = 1/(k_MB + β) and A₀ = B₀ = 1. The x-axis and y-axis are the initial concentrations of the two TFs at time 0. Different initial concentrations of TFs will lead to either on or off states. (a–c) represent the scenario with different levels of miRNA repression efficiency.