Figure 6.

Accommodation of the B[a]P ring system of the dA adduct in the preinsertion position. The adduct in the preinsertion position is directed toward and is crowded by the N-clasp. The color scheme is the same as in Figure 4. The protein is in cartoon mode and the DNA and incoming dNTP are in CPK. (A) The N-clasp is shown in cartoon in order to reveal the position of the B[a]P ring system. The (B) view is the same as (A), except that the N-clasp is shown in CPK. Stereoviews are shown in Supplementary Figure S10.