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. 2008 Oct 8;36(20):6429–6438. doi: 10.1093/nar/gkn670

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — A model relating DCL usage, hairpin structure and MIR-gene evolution. (A) A current model for the evolution of MIR genes by inverted duplication of the founder target gene (black arrow) to give a long IR (head-to-head black arrow) (15), which we designate a proto-MIR gene. (B) Our model for changes in hairpin precursor structure, DCL usage and miRNA size as MIR genes evolve. Hairpin sequences that have diverged in evolution are shown in red; conserved sequences are shown in gray. The approximate contribution of different DCLs to processing is reflected by their font size. The miRNA size generated is indicated on the right.