Table II.
Genes associated with type I IFN signaling are up-regulated in vivo during infection: in vivo microarray analysis
| Accession No. | Fold Change | Description |
|---|---|---|
| Inflammatory/stress and immune responses | ||
| Acute phase response | ||
| Inflammation | ||
| M64404 | 2.72 | IL-1R antagonist |
| Other | ||
| NM_011315 | 3.23 | Serum amyloid A3 |
| NM_011314 | 13.5 | Serum amyloid A2 |
| NM_008491 | 4.44 | Lipocalin 2 |
| BC057985 | 2.86 | Orosomucoid 2 |
| M33215 | 2.11 | β-galactoside-binding lectin (L-34) |
| IFN-inducible | ||
| IFN-α/β-associated | ||
| NM_016850 | 11.66 | IFN regulatory factor 7 (Irf7) |
| NM_008390 | 5.78 | IFN regulatory factor 1 (Irf1) |
| NM_008394 | 2.44 | IFN regulatory factor 9 (Isgf3γ) |
| NM_015783 | 14.43 | IFN-stimulated gene 15 (Isg15) |
| NM_029803 | 7.04 | IFN-stimulated gene 12 (Isg12) |
| NM_011909 | 11.35 | Ubiquitin-specific protease 18 (usp18/ubp43) |
| S48937 | 2.60 | p68 kinase (IFN-inducible dsRNA-activated protein kinase) |
| NM_145211 | 2.56 | 2′-5′ oligoadenylate synthetase 1A |
| NM_145227 | 3.70 | 2′-5′ oligoadenylate synthetase 2 |
| NM_145226 | 2.77 | 2′-5′ oligoadenylate synthetase 3 |
| NM_010846 | 10.37 | Myxovirus (influenza virus) resistance 1 (Mx1) |
| IFN-γ-associated | ||
| NM_008390 | 5.78 | IFN regulatory factor 1 (Irf1) |
| NM_008320 | 3.24 | IFN regulatory factor 8 (Irf8) |
| NM_008394 | 2.44 | IFN regulatory factor 9 (Isgf3γ) |
| AK002545 | 9.94 | IFN-inducible protein 1 |
| NM_027320 | 4.03 | IFN-induced protein 35 |
| NM_172648 | 3.81 | IFN-activated gene 205 |
| NM_008329 | 9.30 | IFN-activated gene 204 |
| NM_008330 | 10.42 | IFN-γ -inducible protein 47 |
| NM_018738 | 11.77 | IFN-γ -induced GTPase |
| NM_019440 | 9.30 | IFN-inducible GTPase 2 |
| NM_021792 | 10.78 | IFN-inducible GTPase 1 |
a
Total RNA was harvested from adherent spleen, liver, and peritoneal cell populations taken from uninfected and infected C57BL/6J mice 72 h postinfection. Total RNA from these three cell populations was pooled, and changes in gene expression were assessed by microarray analysis. Shown are a subset of genes up-regulated 2-fold or more over background in cells from the liver, spleen, and peritoneum of infected mice.