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. 2008 Oct 21;9(Suppl 1):S2. doi: 10.1186/1471-2091-9-S1-S2

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Copyright © 2008 Sato et al; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Functional network of BRCA1 and its interacting proteins that maintains genomic stability. Mauve: putative substrates for the BRCA1-BARD1 E3 ligase. Aqua: proteins encoded by genes that cause familial breast cancer or increase the risk of getting breast cancer. Please note that Swiss-Prot entry name synonyms have been used in figure – common synonyms are given in brackets: CHK2 (Chk2); CHK1 (Chk1); RBBP8 (CtIP); TOPB1 (TopBP1); FANCJ (BACH1/BRIP1); MRE11 (Mre11); RAD50 (Rad50); NBN (Nbs1); RPB1 (Pol II [RPB1]); RPAB3 (RPB8); CSTF1 (CstF50); P53 (p53); ZN350 (ZBRK1); ESR1 (ER-α); PRGR (PR); STK6 (Aurora A); NPM (NPM1/B23); BRCA2 (FANCD1); RAD51 (Rad51); PALB2 (FANCN); SMCA4 (BRG1).