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. 2008 Nov 17;183(4):579–581. doi: 10.1083/jcb.200810125

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© 2008 Scorrano

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Localized production of active, cleaved BID on cardiolipin platforms that are used for the assembly of active caspase 8. The diagram depicts the sequence of events that occur in type II cells according to Gonzalvez et al. (2008). DD, death domain; DED, death effector domain; p10 and p18 are the catalytic core of the caspase. The p43/p10 caspase 8 isoform comprises two DEDs, one p10, and one p18 domain. The cardiolipin (yellow heads) platform at the contact sites between inner and outer mitochondrial membranes is used to produce active BID where it is needed. This in turn causes BAK/BAX oligomerization and cytochrome c release.