Table 4.

Effect of estradiol in the animal on isolated GnRH neurons

Property	OVX	OVX+E
Membrane properties
Capacitance	8.90 ± 0.30 pF	9.00 ± 0.29 pF
	n = 58	n = 54
Input resistance	1.73 ± 0.12 GΩa	2.48 ± 0.19 GΩ
	n = 13	n = 9
Action potential
Amplitude	119.34 ± 3.1 mV	116.73 ± 3.1 mV
	n = 18	n = 18
Duration (at 1/2 amplitude)	1.57 ± 0.07 msec	1.56 ± 0.07 msec
	n = 18	n = 18
Whole-cell current density
Inward (picoampere per picofarad)	−751.9 ± 37.3b	−593.0 ± 33.6
	n = 31	n = 36

Estradiol affects input resistance and whole-cell inward current density in the isolated cell preparation. 

^aSignificantly different from OVX+E (P = 0.003, two-way ANOVA). 

^bSignificantly different from OVX+E (P = 0.002, two-way ANOVA).