Table 3.
Quantitative autoradiography of Ang II receptors in adrenal gland
| Vehicle-saline | Candesartan-saline | Vehicle-LPS | Candesartan-LPS | |
|---|---|---|---|---|
| Zona glomerulosa | ||||
| AT1 | 214 ± 15 | 83 ± 11a | 258 ± 17 | 85 ± 9a |
| AT2 | 135 ± 9 | 125 ± 15 | 113 ± 10 | 92 ± 11 |
| Medulla | ||||
| AT1 | ND | ND | ND | ND |
| AT2 | 480 ± 26 | 365 ± 14a | 485 ± 20 | 320 ± 27a |
Rats treated with vehicle or AT1 antagonist for 3 d received an ip injection of sterile saline or LPS on d 3. The animals were killed 3 h later. Values are mean ± sem for groups of seven to nine animals measured individually and are expressed as fmol/mg protein. ND, Nondetectable.
a
P < 0.001, as compared with vehicle-treated groups; one-way ANOVA and post hoc Tukey’s test.