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. 2008 Jun 19;149(10):4997–5003. doi: 10.1210/en.2007-1634

Figure 1.

Figure 1

Representative bright-field photomicrographs of GnRH ICC in parasagittal sections of Fgf8 hypomorphs. WT (A) and homozygous HOMO (B) E11.5 embryos are shown. Note the presence of GnRH-IR neurons (black arrows) in the invaginated medial-ventral olfactory epithelium (boxed) of WT but not in HOMO embryos. Black asterisk indicates preoptic recess. Black scale bar, 200 μm or 100 μm (inset). C and D, Inverted bright-field photomicrographs of WT and HOMO E14.5 embryos. Note the presence of GnRH-IR neurons in the preoptic area of WT but not in HOMO embryos. White arrow indicates the olfactory bulb. White asterisk indicates the sphenoid cartilage. #, Lateral ventricle. White scale bar, 500 μm or 50 μm (inset). Insets are higher-magnification photomicrographs of the boxed areas.