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. 2008 Jun 19;149(10):4997–5003. doi: 10.1210/en.2007-1634

Figure 5.

Figure 5

GnRH neurons in Fgfr1 hypomorphs on PN 0. A and B, Representative photomicrographs of GnRH-IR neurons (arrows). C and D, GnRH mRNA positive (arrows) in coronal sections of the preoptic area in WT and HOMO Fgfr1 hypomorphs. Asterisk indicates third ventricle. Dotted line indicates ventral border of preoptic area. Scale bar, 50 μm or 20 μm (inset). E, Total number of GnRH-IR neurons in the whole head of WT (n = 4), HET (n = 4), and HOMO (n = 4) Fgfr1 hypomorphs. Different letters indicate significant differences (P < 0.01). Data are presented as mean ± sem.