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Neuroendocrine changes after ES persist to adulthood. A, ES led to elevated basal plasma CORT levels (n = 3/group; *, P < 0.05, t test). B, CRH mRNA in the PVN was significantly reduced in ES mice (n = 3), compared with controls (n = 4; *, P < 0.05, t test). Representative sections are shown. Arrowhead, PVN; vertical line, third ventricle. C. Weights of 3- to 4-month-old ES (n = 11) and control (n = 10) mice were not significantly different (P > 0.05, t test).
