Table 1.
Effect of 10 nmol/liter leptin on GE, GI, and glucose nonresponsive (NG) VMN neurons at 2.5 vs. 0.5 mmol/liter glucose
| 2.5 mmol/liter glucose
|
0.5 mmol/liter glucose
|
|||||
|---|---|---|---|---|---|---|
| GE | GI | NG | GE | GI | NG | |
| LepE | 31 (22/71) | 20 (16/80) | 21 (31/146) | 28 (7/25) | 23 (5/22) | 25 (16/64) |
| LepI | 14 (10/71) | 18 (14/80) | 25 (37/146) | 12 (3/25) | 14 (3/22) | 22 (14/64) |
| LepN | 55 (39/71) | 62 (50/80) | 54 (79/146) | 60 (15/25) | 63 (14/22) | 53 (34/64) |
Changes in [Ca2+]i oscillations at varying glucose concentrations from 2.5 to 0.5 to 2.5 or 0.5 to 2.5 to 0.5 mmol/liter glucose, followed by exposure to 10 nmol/liter leptin were assessed in dissociated VMN neurons. Data are mean percentage of total tested, with number of neurons identified over the total number of neurons tested given in parentheses. LepN, Leptin nonresponsive.