Figure 1.

DN and oxidative (Ox) stress measures. Panel A, Hind paw withdrawal latency was increased in diabetic (D) mice and reduced by Rosi treatment (D+Rosi). Panel, B, Sural sensory NCV was reduced in diabetic mice. Panel, C, Sciatic motor NCV was reduced in diabetic mice. Hind paw latency, sural sensory NCV, and sciatic motor NCV were not affected by Rosi treatment in control (C) mice (C, C plus Rosi). Panel D, The dityrosine to tyrosine ratio was increased in diabetic mice, and reduced by Rosi treatment. Dityrosine was still increased in diabetic mice treated with Rosi compared with control mice treated with Rosi. E, HODE was increased in diabetic mice and decreased by Rosi treatment. There was no difference between control and diabetic mice treated with Rosi. F, There is a significant correlation between thermal latency and dityrosine ratio. *, P < 0.05; **, P < 0.01; ***, P < 0.001.