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Patterns of gene regulation. Each line is the fold change vs. control of one gene across the three different conditions. Genes regulated by both diabetes and Rosi were found to either increase with diabetes and decrease with Rosi treatment (A), or decrease in expression in diabetes and increase with Rosi treatment (B). C, The gene expression pattern of eight genes down-regulated by diabetes and up-regulated by Rosi was confirmed by real-time RT-PCR.
