Table 2.

DAVID enrichment categories

Overall function	Median enrichment P value
Metabolism	3.75 × 10−5
Metal ion binding	9.57 × 10−4
mRNA processing	3.60 × 10−4
Cellular regulation	7.75 × 10−3
Mitochondria and energy production	1.25 × 10−2

Genes significantly regulated in diabetes relative to control were analyzed with the DAVID Functional Annotation Clustering. The table lists the top five nonredundant functional clusters and the median P value of each member of the cluster. The enrichment P value is the probability of finding as many regulated genes in a functional category as were observed, calculated using Fisher’s exact test. Because DAVID clusters annotation from over 40 different sources, including GO, KEGG, and Swiss-prot, the median P value from each cluster was used to rank its relative significance.