Table 5.
Promoter modules significantly altered in regulated metabolic and mitochondrial genes
| Promoter module | Fold change in frequency | P value |
|---|---|---|
| Up-regulated genes | ||
| NF1F_NR2F_01 | 3.88 | 0.001 |
| SP1F_MYOD_01 | 2.44 | 0.03 |
| STAT_ETSF_03 | 2.44 | <0.001 |
| ETSF_ETSF_01 | 2.34 | 0.02 |
| ETSF_SP1F_04 | 2.18 | 0.006 |
| SORY_ETSF_01 | 1.70 | <0.001 |
| ETSF_IRFF_01 | 1.18 | <0.001 |
| IRFF_ETSF_01 | 1.13 | 0.001 |
| NFKB_NKXH_01 | 0.82 | <0.001 |
| Down-regulated genes | ||
| NFKB_AP1F_01 | 10.01 | 0.003 |
| SP1F_EBOX_SP1F_01 | 7.16 | 0.002 |
| EREF_SF1F_01 | 4.32 | 0.03 |
| SP1F_SP1F_01 | 2.75 | 0.03 |
| ETSF_SP1F_04 | 2.18 | 0.05 |
| SORY_ETSF_01 | 2.12 | 0.002 |
| NFKB_NKXH_01 | 1.53 | <0.001 |
| ETSF_IRFF_01 | 0.94 | 0.03 |
Promoter modules are the experimentally characterized combination of TF binding sites found in the promoter region of the regulated genes. Fold change in frequency is the fold change in the percentage of genes with this promoter module in the regulated genes compared with all mouse promoters. The P value is the probability of finding this degree of change in frequency by chance, calculated using Fisher’s exact test.