Table 6.
Top five significantly enriched and regulated TF binding motifs
| TF module | FrameWorker P value | GSEA P value |
|---|---|---|
| SP1F_ZBPF | 9.94E-04 | 1.50E-02 |
| EGRF_EGRF | 2.27E-03 | 3.07E-02 |
| ZBPF_EGRF | 2.16E-03 | 5.77E-02 |
| ETSF_ETSF | 7.77E-06 | 1.22E-01 |
| ZBPF_SP1F_SP1F | 7.81E-06 | 1.27E-01 |
FrameWorker P values are the probability that the binding motif could be found in the promoter region of a set of genes by chance. The module search is performed repeatedly on randomly selected promoter regions to approximate the frequency of matching a promoter sequence by chance. This distribution is the basis for a Z test to determine how likely it is that the genes were found by chance. GSEA P values are the probability that a random gene set could show the same degree of directional regulation as was found in the query gene set.