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. 2008 Nov 17;3(11):e3740. doi: 10.1371/journal.pone.0003740

Figure 5. PPARA and BMP7 signaling pathways in chondrocytes.

Figure 5

(A) Assessment of IL1B and MMP13 mRNA levels after down-regulation of PPARA, 24 and 48 h after siRNA liposomal treatment into chondrocytes. (B) IL1B and MMP13 expression 24 and 48 h after BMP7 siRNA treatment. (C) Evaluation and correlation of BMP7 and ACAN (aggrecan) mRNA levels in normal and osteoarthritic chondrocytes assessed by real-time PCR analysis. (D) Aggrecan expression levels 48 h after BMP7 inhibition of expression using siRNA transferred by liposomes into normal chondrocytes. All experiments have been performed in triplicate.