TABLE 4.
Summary of studies using hormonal therapy for gastrointestinal vascular malformations
| Author (reference) | Type of study | Control (n) | Treated (n) | Transfusions before | Transfusions after | P | Follow-up before (months) | Follow-up after (months) |
|---|---|---|---|---|---|---|---|---|
| Van Cutsem et al (57) | DB, crossover | 13 | 13 | 1.94/month | 0.18/month | 0.002 | 12 to 36 | 6 |
| Lewis et al (21) | Controlled | 34 | 30 | 1.8/month* 2.2/month† |
1.6/month
1.5/month |
NS | 13.4* 15.6† |
|
| Barkin and Ross (55) | Crossover, controlled | 43 | 43 | 1.1/month | 0/month | <0.05 | 44.6 (n=38)
(29.5) (n=5)‡ |
|
| Junquera et al (22) | DB, RCT | 35 | 33 | 1.76±1.5/12 months* 1.8±2.1/12 months† |
NS | 20 (12 to 36) |
*
Control;
†
Treated;
‡
All five patients treated with only estrogen failed. DB Double-blind; NS Not significant; RCT Randomized controlled trial