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Probabilities of over- or underrepresentation of disease-causing genes in the respective phylostrata. Log-odds ratios show how the frequency of disease genes in each phylostratum deviates from the expected one estimated from the whole set of genes. Numbering of the phylostrata corresponds to those in figures 1 and 2 (*P < 0.05; **P < 0.01; ***P < 0.001, two-tailed hypergeometric test corrected for multiple comparison by FDR at 0.05 level).
