Table 1.

Comparison of Overrepresented GO Terms among the Disease Gene Set with the Rank Order of the Same Term among the Overrepresented GO Terms in the Whole Gene Set

PS	GO Term Overrepresented among Disease Genes	Rank among All Genes
1	Metabolic process	1
	Electron transport	4
	Protein amino acid phosphorylation	3
	Carbohydrate metabolic process	5
	Phosphate transport	28
	Proteolysis	3
	Ion transport	8
	Transport	15
	Homophilic cell adhesion	7
	Epidermis development	n.s.
2	Regulation of transcription, DNA dependent	1
	Multicellular organismal development	n.s.
	Protein amino acid dephosphorylation	30
	Ubiquitin cycle	3
	Regulation of Rho protein signal transduction	7
	Transcription	2
	Dephosphorylation	49
	Organ morphogenesis	n.s.
	Forebrain development	n.s.
3	Regulation of transcription, DNA dependent	1
	Transcription	2
4	Transcription	3
	Regulation of transcription, DNA dependent	2
	Positive regulation of transcription from RNA polymerase II promoter	4
	Multicellular organismal development	5
	Wnt receptor signaling pathway, calcium modulating pathway	1
5	G-protein–coupled receptor protein signaling pathway	1
	Signal transduction	3
	Activation of adenylate cyclase activity	15
	Protein–chromophore linkage	16
	Regulation of transcription	9
	Brown fat cell differentiation	41
	G-protein signaling, coupled to cyclic nucleotide second messenger	5
	G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	7
	Sensory perception of taste	n.s.
	Diet-induced thermogenesis	34
	G-protein signaling, coupled to cAMP nucleotide second messenger	14
	Heat generation	37
	Heat generation	37
	Vasodilation by norepinephrine–epinephrine involved in regulation of systemic arterial blood pressure	35
	Phototransduction	20
6	Cell communication	1
	Cell–cell signaling	3
7	Methylation	1
8	Calcium-independent cell–cell adhesion	1
9	Immune response	2
	Antigen processing and presentation	1
	Antigen processing and presentation of peptide antigen via MHC class I	4
	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	3
	Peripheral nervous system development	23
10	Cell surface receptor–linked signal transduction	4
	Response to virus	1
	Immune response	2
	Feeding behavior	12
	Cell–cell signaling	3
	Cellular calcium ion homeostasis	8
	Neutrophil apoptosis	16
	Inflammatory response	5
	JAK–STAT cascade	20
11	None
12	Immune response	1
13	Lipoprotein metabolic process	1
	Lipid transport	4
	Negative regulation of lipid catabolic process	n.s.
	Neutrophil activation	n.s.
	Regulation of cytokine production	n.s.
	Negative regulation of lipoprotein metabolic process	n.s.
	Cell surface receptor–linked signal transduction	n.s.
	Regulation of cholesterol absorption	n.s.
	Positive regulation of interleukin-8 biosynthetic process	n.s.
14	None
15	Keratinization	4
	Peptide cross-linking	n.s.
	Keratinocyte differentiation	n.s.
	Protein homooligomerization	n.s.
16	None
17	None

NOTE.—“n.s.” means that the term was not significantly overrepresented in the whole gene set.