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. 2008 Aug 5;80(3):453–462. doi: 10.1093/cvr/cvn209

Figure 4.

Figure 4

Effects of inhibition of src-family kinase and Rho-kinase on MYPT-1 (120–130 kDa) and MLC20 (18 kDa) phosphorylation. (A) In the presence of PGF2α, hypoxia greatly enhanced phosphorylation (**P < 0.001 vs. control, n = 17 rats for both sites), and this enhancement was reversed by SU6656 (†P < 0.01, n = 10 rats for both sites) and Y27632 (††P < 0.001, n = 6 rats for both sites). (B) In the absence of PGF2α, a smaller but still significant increase was apparent (*P < 0.01, n = 17 rats for both sites), and this increase too was inhibited by SU6656 (†P < 0.01, n = 10 rats for both sites) and Y27632 (††P < 0.001, n = 6 rats for both sites). (C) Five micromolar PGF2α also enhanced phosphorylation (*P < 0.01, n = 13 rats for both sites). This increase was significantly reduced by both SU6656 [†P < 0.01 (MYPT-1 only), n = 9 rats for both sites] and Y27632 (††P < 0.001, n = 6 rats for both sites).