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. 2008 Aug 5;80(3):453–462. doi: 10.1093/cvr/cvn209

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

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Hypoxia-mediated translocation of Rho-kinase in pulmonary artery smooth muscle cells: effects of src and fyn knockdown. (A–C) Examples of ROCK-2 staining in pulmonary artery smooth muscle cells either sham-transfected (A) or transfected with src-siRNA (B) or fyn-siRNA (C), under either normoxic (left panels) or hypoxic conditions (right panels). (D) Hypoxia-induced ROCK-2 translocation, as determined by the ratio of cytosol/nuclear staining intensity. *P < 0.01 vs. normoxia; ^†P < 0.01 vs. sham-transfected. n = 4 experiments (in cells from four different rats).