Figure 1.

Expression and localization of recombinant human tissue kallikrein in rat heart reduced infarct size at 10 days after acute myocardial infarction (MI). (A) Representative immunohistochemistry photographs of recombinant human tissue kallikrein in the infarcted region. Original magnification is ×200. (B) Representative reverse transcriptase–polymerase chain reaction products of human tissue kallikrein mRNA. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) served as an internal control. (C) Representative Masson’s trichrome staining. Original magnification is ×10. (D) Quantitative analysis of infarct size. Infarct size is expressed as percentage of the infarct/left ventricle area. Values are expressed as mean ± SEM (n = 6–8, *P < 0.01 vs. other myocardial infarction groups).