Table 2.

Significant atrophy in Alzheimer's patients

Anatomic area	Brodmann area	Talairach coordinates			Z-score	Cluster-level, P-value	Voxel-level, P-value
		x	y	z
L medial temporal	28/35	−24	−8	−12	7.39	0.000	0.000
L middle temporal	21	−48	−72	28	6.88	0.000	0.000
L cingulate	32	−4	23	32	6.47	0.000	0.000
R medial temporal	28/35	24	−35	−10	7.12	0.000	0.000
R superior frontal	10	20	6	49	5.23	0.000	0.026
R cingulate	32	6	−2	30	5.63	0.000	0.003
R inferior parietal	40	46	−42	50	5.18	0.000	0.035
R caudate		14	10	14	6.52	0.000	0.000
ROI analysis (correlation with performance)
ROI
Lateral temporal ROI		−65	−22	−12	3.13	0.000	0.000
Occipital ROI		−36	−80	28	3.95	0.000	0.000
Occipital ROI		−16	−66	48	3.33	0.001	0.000
		−32	−41	28	3.67	0.001	0.001
Medial temporal ROI	No significant clusters