. Author manuscript; available in PMC: 2009 Oct 1.

Published in final edited form as: Bioorg Med Chem. 2008 Sep 9;16(19):8795–8800. doi: 10.1016/j.bmc.2008.09.016

Table 1.

Irradiation and NOE data for cytidine and its methylated analogues at 4, 25, and 37 °C.

Compound	Irradiated proton	Enhanced proton	NOE %
			4 °C	25 °C	37 °C
C	H6	H1′	3.3	4.9	4.3
(D₂O)		H2′ + H3′	8.6	9.5	8.1
		H5	7.3	11.4	10.1
	H1′	H6	1.8	3.1	3.1
	H2′	H6	5.6	6.0	5.2
	H3′	H6	2.8	3.0	2.6

Cm	H6	H1′	3.5	3.7	3.6
(D₂O)		H2′ + H3′	6.7	8.4	7.6
		H5	9.2	10.8	9.4
	H1′	H6	2.2	4.1	2.8
	H2′	H6		5.5	4.9
	H3′	H6	2.9	3.7	2.6

m⁴C	H6	H1′	4.7	8.5	4.8
(D₂O)		H2′ + H3′	10.5	12.2	10.7
		H5	8.2	11.6	9.2
	H1′	H6	1.7	2.3	1.9
	H2′	H6	6.2	5.8	4.5
	H3′	H6	2.2	1.9	1.9

m⁴Cm	H6	H1′ + H5	5.4	17.6	16.1
(D₂O)		H2′ + H3′	7.2	11.9	10.9
	H1′	H6	1.5	4.8	4.2
	H2′	H6	4.3	6.0	5.2
	H3′	H6	1.9	2.8	2.4

m⁴Cm	H6	H1′	3.4	3.4	3.3
(CD₃OD)		H2′ + H3′	11.0	8.7	8.5
		H5	11.2	9.3	8.9
	H1′	H6	2.7	2.1	2.3
	H2′	H6	3.9	3.4	3.3
	H3′	H6	5.0	3.5	3.1