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Effect of 2-MeSADP and UDP on insulin secretion in mouse islets in culture. The islets were incubated in Krebs/HEPES buffer (pH 7.4) containing 5.5 mM (G5.5, a) or 16.7 mM glucose (G16.7, b) in the presence of 100 μM 2-MeSADP or 200 μM UDP for 60 min at 37°C. Each bar represents the mean ± SE (n = 8 in a and n = 10 in b). *P < 0.05 in comparison to control in the absence of nucleotides
