Table 2.

Analysis of haplotypes in the COMT gene

Haplotype	Case	freq	Control	freq	OR	chisq	p
rs737865 - rs165688*
A-Val	325	0.520	289	0.580	1	3.962	0.046
A-Met	211	0.338	130	0.261	1.443	7.84	0.005
G-Val	88	0.141	79	0.158	0.990	0.675	0.411
rs165688* - rs165599
Val-A	341.5	0.542	308.2	0.604	1	4.547	0.032
Val-G	73.51	0.116	63.77	0.125	1.04	0.277	0.598
Met-A	86.51	0.137	53.77	0.105	1.452	2.829	0.092
Met-G	128.5	0.204	84.23	0.165	1.377	3.282	0.070
rs737865 - rs165599
A-A	358.8	0.555	295.2	0.583	1	0.879	0.348
A-G	184.2	0.285	127.8	0.252	1.186	1.535	0.215
G-A	76.22	0.118	62.81	0.124	0.998	0.175	0.675
G-G	26.78	0.041	20.19	0.039	1.091	0.107	0.742
rs737865 - rs165688* - rs165599
A-Val-A	259.6	0.437	230.7	0.470	1	1.274	0.259
A-Val-G	59.42	0.10	57.27	0.116	0.922	0.929	0.335
A-Met-A	78.42	0.132	47.27	0.096	1.475	3.673	0.055
A-Met-G	120.6	0.203	81.73	0.166	1.311	2.566	0.109
G-Val-A	76	0.127	73	0.149	0.925	0.998	0.317

Best p-value 0.00511

Global significance after permutation correction: p=0.0263 SE: 0.0016

^*rs165688 = Val158Met (Val=G) = rs4680