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MMP inhibition reduces disease activity in patients with severe periodontitis. Effect of SDD on clinical attachment loss ≥2 mm from baseline to 9 months. Tooth sites were stratified by degree of disease severity, based on PD at baseline. Mean per-patient percentages (± SE) are presented. The more severe the disease state, the greater the observed attenuation of disease activity by SDD therapy. Adapted from reference 22.
