. Author manuscript; available in PMC: 2009 Aug 1.

Published in final edited form as: J Periodontol. 2008 Aug;79(8 Suppl):1592–1600. doi: 10.1902/jop.2008.080174

Table 1.

Chemokines Are Proteolytically Processed by MMPs During Wound Healing and Inflammation

Chemokine	MMP								ADAM		Legend
Chemokine	1	2	3	7	8	9	13	14	10	17	Legend
CCL2(MCP1)											Not tested
CCL5 (RANTES)											Not cleaved
CCL7 (MCP3)											Unknown effect
CCL8 (MCP2)											Unknown effect
CCL13(MCP4)											Variable effect
CXCL1 (KC)											Variable effect
CXCL1 (GROα)											Increases activity
CXCL2 (MIP2)											Increases activity
CXCL2 (GROβ)											Decreases activity
CXCL2 (DCIP1)											Decreases activity
CXCL2 (GROγ)											Degraded
CXCL4 (PF4)											Creates receptor antagonist
CXCL5 (LIX)					◦
CXCL5 (ENA78)					◦
CXCL6 (GCP2)											Creates toxic protein
CXCL7 (NAP2)
CXCL8 (1L8)					◦
CXCL12 (SDF1)		•									• = tested in vivo
CXCL16											• = tested in vivo

Reprinted with permission from Elsevier.⁸