Table 2.
Risk estimates for eleven SNPs showing an association with breast cancer in the Breast Cancer Association Consortium that were genotyped in the U.S. Radiologic Technologists study
| Gene | Entrez SNP ID* | Genotype | Cases (%)
(n=859) |
Controls (%)
(n=1083) |
OR‡ | 95% CI | p- value | |
|---|---|---|---|---|---|---|---|---|
| FGFR2 | rs2981582 | CC | 267 (32) | 407 (38) | 1.0 | |||
| TC/TT | 555 (68) | 670 (62) | 1.3 | 1.0 | 1.5 | 0.02 | ||
| TNRC91 | rs12443621 | TT | 201 (24) | 293 (27) | 1.0 | |||
| CT/CC | 621 (76) | 775 (73) | 1.2 | 1.0 | 1.4 | 0.1 | ||
| TNRC92 | rs8051542 | GG | 235 (29) | 339 (32) | 1.0 | |||
| AG/AA | 586 (71) | 735 (68) | 1.1 | 0.9 | 1.4 | 0.2 | ||
| MAP3K1 | rs889312 | AA | 380 (46) | 564 (52) | 1.0 | |||
| CA/CC | 444 (54) | 512 (48) | 1.3 | 1.1 | 1.5 | 0.007 | ||
| LSP1 | rs3817198 | TT | 391 (47) | 481 (45) | 1.0 | |||
| TC/CC | 436 (53) | 599 (55) | 0.9 | 0.7 | 1.1 | 0.2 | ||
| H19 | rs2107425 | GG | 392 (48) | 502 (47) | 1.0 | |||
| AG/AA | 432 (52) | 571 (53) | 1.0 | 0.8 | 1.2 | 0.8 | ||
| POU5F1P1 | rs13281615 | AA | 269 (31) | 398 (37) | 1.0 | |||
| GA/GG | 576 (68) | 683 (63) | 1.2 | 1.0 | 1.5 | 0.02 | ||
| HCN1 | rs981782 | TT | 246 (30) | 318 (30) | 1.0 | |||
| TG/GG | 569 (70) | 755 (70) | 1.0 | 0.8 | 1.2 | 0.8 | ||
| ITGA2 | rs30099 | GG | 706 (85) | 908 (84) | 1.0 | |||
| AG/AA | 126 (15) | 170 (16) | 1.0 | 0.7 | 1.2 | 0.7 | ||
| LOC388927 | rs4666451 | CC | 339 (40) | 419 (39) | 1.0 | |||
| CT/TT | 502 (60) | 659 (61) | 0.9 | 0.8 | 1.1 | 0.5 | ||
| TNRC93 | rs3803662 | CC | 389 (47) | 556 (52) | 1.0 | |||
| TC/TT | 432 (53) | 513 (48) | 1.2 | 1.0 | 1.4 | 0.04 | ||
*
Entrez SNP reference ID number (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=snp)
†
Amino acid sequence variation (regular font), nucleotide sequence variation (italics)
‡
Adjusted for year of birth
§
Genotype frequencies in controls did not comply with Hardy-Weinberg expectation, (p < 0.001)