Table 3. Mean Difference in LDL-c and HDL-c by Genotype, ARIC.

	Model 1	P-value	Model 2	P-value
LDL-c, mg/dL
Apolipoprotein E
ε22/ε23	-15.7	<0.0001	-16.5	<0.0001
ε34/ε44	6.2	<0.0001	6.4	<0.0001
ε33	-	ref	-	ref
HDL-c, mg/dL
Cholesteryl Ester
Transfer Protein
AA	5.4	<0.0001	5.5	<0.0001
AG	2.2	<0.0001	2.5	<0.0001
GG	-	ref	-	ref
Hepatic Lipase
TT	3.5	<0.0001	3.3	<0.0001
TC	2.2	<0.0001	2.0	<0.0001
CC	-	ref	-	ref
Lipoprotein Lipase
GG/CG	2.8	<0.0001	2.8	<0.0001
CC	-	ref	-	ref

Values are mean differences between genotypes with 1 or 2 copies of the variant allele versus the wildtype over 4 ARIC visits.

Model 1 is adjusted for visit, age, and a combined center/race variable.

Model 2 is model 1 plus the following time-dependent covariates: body mass index, smoking, use of cholesterol lowering medications, use of hormone replacement therapy, and menopausal status.