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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Am J Surg. 2008 Nov;196(5):683–689. doi: 10.1016/j.amjsurg.2008.07.016

Figure 4.

Figure 4

(A) Wound closure on a collagen substrate is reduced when cells are exposed to 20–80 mmHg increased pressure vs. ambient pressure control (n=36 each, P<0.005 for each comparision). (B) 20 and 80 mm Hg pressures reduce migration across fibronectin vs. ambient pressure control (n=24 each, P<0.005 each). (C) Pressure decreases wound closure on a collagen substrate similarly after treatment with a DMSO vehicle control or after ERK blockade by the upstream MEK inhibitor PD 98059 vs. ambient pressure control (n=36 each, P<0.005 each).