β cell recovery is independent of the exocrine pancreas. (A, E) Ins:nfsB-mCherry embryos before prodrug incubation. (B,F) Ablation following 24hrs of prodrug incubation. (C, D, G, H) Following 36hrs of prodrug removal, recovery can be detected. Control embryos (A – D), show normal exocrine pancreas as demonstrated by CPA immunofluorescent detection (pseudo color image D). Ptf1a morphant embryos shown in E to H lack an exocrine pancreas as demonstrated by absence of CPA (H), but still recover β cells (G).