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. 2000 Apr 18;97(10):5357–5362. doi: 10.1073/pnas.090013497

Figure 2.

Figure 2

Chromosome banding, FISH, and Giemsa stain analyses. (A) Ring chromosome and telomeric associations in a low-grade MFH. (B) Anaphase bridge in the same case. (C) A dicentric chromosome (arrow) visualized by FISH with a probe for all human centromeres (red) in the pancreatic carcinoma cell line LPC5. (D) Chromatin bridges between interphase nuclei in an atypical lipomatous tumor with ring chromosomes containing amplified sequences from 12q; the bridges are positive with the 12q probes 751a4 (red) and 2 g11 (green). (E) Combinations (n = 9) of structural rearrangements involving chromosome 9 material (white classification color), found by spectral karyotyping of MFH1. (F) Dicentric chromosomes containing material from chromosome 3 (dark blue) shown by combined binary and ratio labeling FISH (Upper) and inverted 4′,6-diamidino-2-phenylindole staining (Lower) in MFH2. (G) Combinations (n = 13) of structural rearrangements involving material from chromosome 1 detected by whole-chromosome painting (red) in MM. (H) Complete (at the top and right) and broken (on the left) internuclear chromatin bridges positive for whole-chromosome-9 paint (green) in MFH1.