Table 1.
Distribution of bridge-breakage instability* in solid tumors
| Diagnosis | Karotypic features† |
Bridge-breakage instability in low-passage cultures | Bridge-breakage instability in cell lines |
|---|---|---|---|
| High intercellular heterogeneity | 30 /31 | 11 /14 | |
| Low/borderline malignant | 19 /19 | — | |
| Atypical lipomatous tumor | r | 17 /17 | — |
| MFH | r and tas | 1 /1 | — |
| Desmoid tumor | tas | 1 /1 | — |
| Highly malignant | 11 /12 | 11 /14 | |
| Leiomyosarcoma | Complex | 2 /2 | — |
| MFH | Complex | 3 /3 | — |
| Malignant melanoma | Complex | — | 1 /1 |
| Osteosarcoma | Complex | 2 /2 | 2 /2 |
| Ovarian carcinoma | Complex | — | 1 /1 |
| Pancreatic carcinoma | Complex | — | 7 /10 |
| Sarcoma, NOS | Complex | 4 /5 | — |
| Low intercellular heterogeneity | 0 /9 | 0 /2 | |
| Benign | 0 /5 | — | |
| Hibernoma | t(6;14;11) | 0 /1 | — |
| Leiomyoma | t(12;14) | 0 /1 | — |
| Lipoma | t(1;6;5) | 0 /3 | — |
| t(2;6) | |||
| del(14q) | |||
| Low malignant | 0 /1 | — | |
| Dermatofibrosarcoma protuberans | r(17;22) | 0 /1 | — |
| Highly malignant | 0 /3 | 0 /2 | |
| Myxoid liposarcoma | t(12;16) | 0 /2 | 0 /1 |
| Synovial sarcoma | t(X;18) | 0 /1 | — |
| Ewing sarcoma | Complex with t(11;22) | — | 0 /1 |
*
More than 2% of anaphase figures with bridges and more than 4% of metaphase cells containing at least one ring chromosome, dicentric chromosome, or telomeric association.
† t, translocation; del, deletion; r, ring chromosome; tas, telomeric association; a complex karyotype contains more than five structural aberrations.