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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Adv Enzyme Regul. 2008 Feb 21;48:113–135. doi: 10.1016/j.advenzreg.2008.02.006

Figure 4. Targeting Signal Transduction Pathways in Breast Cancer.

Figure 4

Potential sites of action of small molecular weight inhibitors and cytotoxic antibodies are indicated. In some cases inhibitors will suppress growth, apoptotic and cell cycle regulatory pathways. This diagram serves to illustrate the concept that targeting PI3K/PTEN/Akt/mTOR and Raf/MEK/ERK pathways can have dramatic effects on many growth regulatory molecules. Proteins inactivated by S/T phosphorylation induced by the PI3K/PTEN/Akt/mTOR and Raf/MEK/ERK pathways are shown in black circles with white P in a black circle.